For research use only. Not for therapeutic Use.
CR-665, also known as FE-200665 and JNJ-38488502, is a kappa-opioid agonist potentially for the treatment of postoperative pain.
| Catalog Number | I006292 |
| CAS Number | 958873-83-1 (CR-665 Acetate ) |
| Synonyms | CR-665; FE-200665; JNJ-38488502; CR665; FE200665; JNJ38488502; CR 665; FE 200665; JNJ 38488502;;(R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-N-((R)-1-amino-5-guanidino-1-oxopentan-2-yl)-N-(pyridin-4-ylmethyl)hexanamide acetate |
| Molecular Formula | C38H53N9O6 |
| Purity | ≥95% |
| Target | kappa-opioid agonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| InChI | InChI=1S/C36H49N9O4.C2H4O2/c1-2-3-15-29(35(49)45(24-27-17-20-41-21-18-27)31(32(38)46)16-10-19-42-36(39)40)43-34(48)30(23-26-13-8-5-9-14-26)44-33(47)28(37)22-25-11-6-4-7-12-25;1-2(3)4/h4-9,11-14,17-18,20-21,28-31H,2-3,10,15-16,19,22-24,37H2,1H3,(H2,38,46)( |
| InChIKey | HJWCYDYBEQFBNK-CKYFGSNBSA-N |
| SMILES | N=C(N)NCCC[C@H](C(N)=O)N(C([C@@H](CCCC)NC([C@@H](CC1=CC=CC=C1)NC([C@@H](CC2=CC=CC=C2)N)=O)=O)=O)CC3=CC=NC=C3.CC(O)=O |
| Reference | </br>1:Thermal Decomposition of Potential Ester Biofuels Part I: Methyl Acetate and Methyl Butanoate. Porterfield JP, Bross DH, Ruscic B, Thorpe JH, Nguyen TL, Baraban JH, Stanton JF, Daily JW, Ellison GB.J Phys Chem A. 2017 May 18. doi: 10.1021/acs.jpca.7b02639. [Epub ahead of print] PMID: 28517940 </br>2:Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. Hemilä H.JRSM Open. 2017 May 2;8(5):2054270417694291. doi: 10.1177/2054270417694291. eCollection 2017 May. PMID: 28515951 </br>3:Energy Efficiency and Productivity Enhancement of Microbial Electrosynthesis of Acetate. LaBelle EV, May HD.Front Microbiol. 2017 May 3;8:756. doi: 10.3389/fmicb.2017.00756. eCollection 2017. PMID: 28515713 Free Article</br>4:Phorbol 12-myristate-13-acetate mediated stabilization of Leukemia Inhibitory Factor ( <i>lif</i> ) mRNA: Involvement of Nucleolin and PCBP1. Chakraborty A, Mukherjee S, Saha S, De S, Sengupta Bandyopadhyay S.Biochem J. 2017 May 16. pii: BCJ20170051. doi: 10.1042/BCJ20170051. [Epub ahead of print] PMID: 28512205 </br>5:A case of anaphylactoid reaction to acetate in acetate-containing bicarbonate dialysate. Misaki T, Suzuki Y, Naito Y, Shiooka T, Isozaki T.CEN Case Rep. 2015 May;4(1):81-84. doi: 10.1007/s13730-014-0144-z. Epub 2014 Sep 4. PMID: 28509276 Free PMC Article</br>6:Hypersensitivity reactions to acetate in the bicarbonate dialysate in a patient undergoing pre-dilution online hemodiafiltration. Kato A, Takita T, Furuhashi M.CEN Case Rep. 2016 May;5(1):31-33. doi: 10.1007/s13730-015-0185-y. Epub 2015 May 1. PMID: 28509160 Free PMC Article</br>7:Effect of the injectable contraceptive depot-medroxyprogesterone acetate on coagulation parameters in new users. Melhado-Kimura V, Bizzacchi JMA, Quaino SKP, Montalvao S, Bahamondes L, Fernandes A.J Obstet Gynaecol Res. 2017 May 15. doi: 10.1111/jog.13306. [Epub ahead of print] PMID: 28503774 </br>8:The role of 2D/3D spin-polarization interactions in hybrid copper hydroxide acetate: new insights from first-principles molecular dynamics. Chaker Z, Ori G, Boero M, Massobrio C.Beilstein J Nanotechnol. 2017 Apr 12;8:857-860. doi: 10.3762/bjnano.8.86. eCollection 2017. PMID: 28503395 Free PMC Article</br>9:Effect of conjugated linoleic acid and acetate on milk fat synthesis and adipose lipogenesis in lactating dairy cows. Urrutia N, Harvatine KJ.J Dairy Sci. 2017 May 10. pii: S0022-0302(17)30402-2. doi: 10.3168/jds.2016-12369. [Epub ahead of print] PMID: 28501397 </br>10:A New Mouse Model for Introduction of Aortic Aneurysm by Implantation of Deoxycorticosterone Acetate Pellets or Aldosterone Infusion in the Presence of High Salt. Liu S, Gong MC, Guo Z.Methods Mol Biol. 2017;1614:155-163. doi: 10.1007/978-1-4939-7030-8_12. PMID: 28500602 |
