Crenigacestat

For research use only. Not for therapeutic Use.

  • CAT Number: I001625
  • CAS Number: 1421438-81-4
  • Molecular Formula: C22H23F3N4O4
  • Molecular Weight: 464.44
  • Purity: ≥95%
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Crenigacestat(CAT: I001625) is a potent gamma-secretase inhibitor with significant applications in oncology research. By targeting the Notch signaling pathway, it suppresses the cleavage of Notch receptors, effectively downregulating their activity. This inhibition disrupts tumorigenesis by preventing abnormal cell differentiation and proliferation. Crenigacestat is instrumental in studies focused on solid tumors and hematological malignancies, offering insights into therapeutic interventions targeting Notch-mediated pathways. Its specificity and efficacy make it a valuable tool in cancer-related drug development, aiding researchers in exploring novel therapeutic strategies. Crenigacestat integrates seamlessly into experimental protocols, supporting advancements in oncology and personalized medicine research.


Catalog Number I001625
CAS Number 1421438-81-4
Synonyms

LY3039478; LY 3039478; LY-3039478; 4,4,4-trifluoro-N-[(2S)-1-[[(7S)-5-(2-hydroxyethyl)-6-oxo-7H-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-oxopropan-2-yl]butanamide

Molecular Formula C22H23F3N4O4
Purity ≥95%
Target Stem Cell/Wnt
Solubility DMSO ≥ 35 mg/mL
Storage 3 years -20°C powder
IUPAC Name 4,4,4-trifluoro-N-[(2S)-1-[[(7S)-5-(2-hydroxyethyl)-6-oxo-7H-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-oxopropan-2-yl]butanamide
InChI InChI=1S/C22H23F3N4O4/c1-13(27-17(31)8-9-22(23,24)25)20(32)28-18-15-6-3-2-5-14(15)16-7-4-10-26-19(16)29(11-12-30)21(18)33/h2-7,10,13,18,30H,8-9,11-12H2,1H3,(H,27,31)(H,28,32)/t13-,18-/m0/s1
InChIKey YCBAQKQAINQRFW-UGSOOPFHSA-N
SMILES O=C(N[C@@H](C)C(N[C@H]1C2=CC=CC=C2C3=CC=CN=C3N(CCO)C1=O)=O)CCC(F)(F)F

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