Crenulatin

• CAT Number: I044856
• CAS Number: 63026-02-8
• Molecular Formula: C11H20O6
• Molecular Weight: 248.27
• Purity: ≥95%
• Synonyms: (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(2-methylbut-3-en-2-yloxy)oxane-3,4,5-triol
• InChI: InChI=1S/C11H20O6/c1-4-11(2,3)17-10-9(15)8(14)7(13)6(5-12)16-10/h4,6-10,12-15H,1,5H2,2-3H3/t6-,7-,8+,9-,10+/m1/s1
• InChIKey: ZEGGZNOPAPRAIG-SPFKKGSWSA-N
• SMILES: CC(C)(C=C)OC1C(C(C(C(O1)CO)O)O)O

Crenulatin is a gallotannin that can be isolated from Rhodiola rosea. Crenulatin can be used as a biomarker to identify potentially adulterated R. rosea products. Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, via regulating Fas/Bcl-2 expression and caspase-3 activity[1][2][3].
Crenulatin (25 mg/L, 100 mg/L; 24 h) induces apoptosis at 100 mg/L, and inhibits apoptosis at 25 mg/L, in mouse cerebral microvascular endothelial cells (bEnd. 3 cell line), accompanying with caspase-3 expression increases or decrease, respectivley[3].

Reference

[1]. Marchev AS, et al. Authenticity and quality evaluation of different Rhodiola species and commercial products based on NMR-spectroscopy and HPLC. Phytochem Anal. 2020 Nov;31(6):756-769.
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[2]. W S Yu, et al. Polyphenols from Rhodiola crenulata. Planta Med. 1993 Feb;59(1):80-2.
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[3]. Qian R, et al. Dual-direction effect of crenulatin on apoptosis of cerebral microvascular endothelial cells and it’s mechanism[J]. Chinese Journal of Pathophysiology, 2005: 2086-2090.