For research use only. Not for therapeutic Use.
Crimidine (CAT: I014308) is a convulsant poison that is primarily used as a rodenticide. It was originally marketed under the product name Castrix. Crimidine was developed and produced by the conglomerate IG Farben in the 1940s. As a rodenticide, crimidine is toxic to rodents and is commonly used to control rodent populations. It exerts its effects by causing convulsions in the targeted rodents, leading to their eventual demise. Due to its toxicity and potential risks to humans and non-target animals, the use of crimidine is regulated and restricted to trained professionals for pest control purposes.
| Catalog Number | I014308 |
| CAS Number | 535-89-7 |
| Synonyms | Crimidine; W-491; W-491; W-491; NSC 2017; NSC-2017; NSC2017.;2-Chloro-4-dimethylamino-6-methylpyrimidine |
| Molecular Formula | C7H10ClN3 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C7H10ClN3/c1-5-4-6(11(2)3)10-7(8)9-5/h4H,1-3H3 |
| InChIKey | HJIUPFPIEBPYIE-UHFFFAOYSA-N |
| SMILES | CC1=CC(N(C)C)=NC(Cl)=N1 |
| Reference | </br>1: Zimmermann R, Steinberg TA, Raith K, Hülsmeyer V, Fischer A. Canine status epilepticus due to acute intoxication. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2010;38(5):285-94. PubMed PMID: 22215313.</br>2: Lheureux P, Penaloza A, Gris M. Pyridoxine in clinical toxicology: a review. Eur J Emerg Med. 2005 Apr;12(2):78-85. Review. PubMed PMID: 15756083.</br>3: Besnard T, Sadeg N, Ricart N, Richecoeur J, Nisse P, Vinner E, Houdret N, Humbert L, Ihermitte M. [Serial determination of crimidine by HPLC/SE/SM in a patient ingesting a ‘mouse trap’]. Acta Clin Belg. 2002;57 Suppl 1:8-11. French. PubMed PMID: 11974448.</br>4: Besnard T, Sadeg N, Ricart N, Richecœur J, Nisse P, Vinner E, Houdret N, Humbert L, Lhermitte M. Determination serique de la crimidine par clhp/es/sm chez un patient ayant ingere un « souricide foudroyant ». Acta Clin Belg. 2002;57 Suppl 1:8-11. doi: 10.1179/acb.2002.069. PubMed PMID: 24862517.</br>5: De Saqui-Sannes P, Nups P, Le Bars P, Burgat V. Evaluation of an HPTLC method for the determination of strychnine and crimidine in biological samples. J Anal Toxicol. 1996 May-Jun;20(3):185-8. PubMed PMID: 8735200.</br>6: Sun ZQ. [Single dose of 2 acute rodenticides used in a village]. Zhonghua Liu Xing Bing Xue Za Zhi. 1985 Oct;6(5):296-9. Chinese. PubMed PMID: 3836748.</br>7: Lumeij JT, Schotman AJ, de Vries HW. Crimidine (2-chloro-4-(dimethylamino)-6-methylpyrimidine) poisoning in a dog due to ingestion of the rodenticide Castrix. Vet Q. 1983 Jul;5(3):107-11. PubMed PMID: 6636500.</br>8: KARLOG O, KNUDSEN E. VITAMIN B6 AS AN ANTIDOTE AGAINST THE RODENTICIDE ‘CASTRIX’ (2-CHLORO-4-METHYL-6-DIMETHYLAMINOPYRIMIDIN). Nature. 1963 Nov 23;200:790. PubMed PMID: 14087021.</br>9: KNUDSEN E. THE TOXICITY OF THE RODENTICIDE CASTRIX (2-CHLORO-4-DIAMETHYLAMINO-6-METHYLPYRIMIDINE) AND THE ANTIDOTAL EFFECT OF VITAMIN B6. Acta Pharmacol Toxicol (Copenh). 1963;20:295-302. PubMed PMID: 14162811.</br>10: CRAMPTON JM, VOSS E. An investigation of the chronic toxicity and acceptability of Castrix. J Am Pharm Assoc Am Pharm Assoc. 1952 Mar;41(3):135-8. PubMed PMID: 14927481.</br>11: GOLDBACH H. [Fatal poisoning with castrix (hydrochloride of 2-chlor-4-methyl-6-dimethylaminopyrimidine), a rat poison]. Med Klin. 1950 Aug 4;45(31):961-3. Undetermined Language. PubMed PMID: 15438607.</br>12: DUBOIS KP, COCHRAN KW, THOMSON JF. Rodenticidal action of 2-chloro-4-dimethylamino-6-methylpyrimidine (castrix). Proc Soc Exp Biol Med. 1948 Feb;67(2):169-71. PubMed PMID: 18907617.</br></br> |
