Crocetin

For research use only. Not for therapeutic Use.

  • CAT Number: I009868
  • CAS Number: 27876-94-4
  • Molecular Formula: C20H24O4
  • Molecular Weight: 328.408
  • Purity: ≥95%
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Transcrocetin (Cat No.: I009868), derived from saffron, is a substance known for its remarkable properties. It acts as a high-affinity NMDA receptor antagonist that can penetrate the blood-brain barrier, making it significant in neuroscience research. Additionally, Crocetin, found in saffron as well, exhibits a wide range of functions, including anti-tumor, anti-atherosclerosis, anti-hypertension, and treatment of hemorrhagic shock. Its antioxidant properties, liver protection, and choleretic functions contribute to its diverse applications in health and medicine. For further information or inquiries about Transcrocetin, please feel free to contact us.


Catalog Number I009868
CAS Number 27876-94-4
Synonyms

Crotecin, Trans-crocetin; Transcrocetin; TSC; NSC 407300; Natural Yellow 6; 8,8/’-Diapocarotenedioic acid. ,8/’-Diapo-psi,psi-carotenedioic acid.;(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioic acid

Molecular Formula C20H24O4
Purity ≥95%
Target Neuronal Signaling
Solubility Soluble in DMSO
Storage -20°C
IUPAC Name (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioic acid
InChI InChI=1S/C20H24O4/c1-15(11-7-13-17(3)19(21)22)9-5-6-10-16(2)12-8-14-18(4)20(23)24/h5-14H,1-4H3,(H,21,22)(H,23,24)/b6-5+,11-7+,12-8+,15-9+,16-10+,17-13+,18-14+
InChIKey PANKHBYNKQNAHN-MQQNZMFNSA-N
SMILES CC(=CC=CC=C(C)C=CC=C(C)C(=O)O)C=CC=C(C)C(=O)O
Reference

1: Xiang M, Yang R, Zhang Y, Wu P, Wang L, Gao Z, Wang J. Effect of crocetin on
vascular smooth muscle cells migration induced by advanced glycosylation end
products. Microvasc Res. 2017 Jul;112:30-36. doi: 10.1016/j.mvr.2017.02.004. Epub
2017 Feb 13. Review. PubMed PMID: 28209519.

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2: Moradzadeh M, Sadeghnia HR, Tabarraei A, Sahebkar A. Anti-tumor effects of
crocetin and related molecular targets. J Cell Physiol. 2017 Apr 13. doi:
10.1002/jcp.25953. [Epub ahead of print] Review. PubMed PMID: 28407293.

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3: Bathaie SZ, Farajzade A, Hoshyar R. A review of the chemistry and uses of
crocins and crocetin, the carotenoid natural dyes in saffron, with particular
emphasis on applications as colorants including their use as biological stains.
Biotech Histochem. 2014 Aug;89(6):401-11. doi: 10.3109/10520295.2014.890741. Epub
2014 Mar 25. Review. PubMed PMID: 24665936.

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4: Gutheil WG, Reed G, Ray A, Anant S, Dhar A. Crocetin: an agent derived from
saffron for prevention and therapy for cancer. Curr Pharm Biotechnol. 2012
Jan;13(1):173-9. Review. PubMed PMID: 21466430; PubMed Central PMCID: PMC4461363.

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5: Giaccio M. Crocetin from saffron: an active component of an ancient spice.
Crit Rev Food Sci Nutr. 2004;44(3):155-72. Review. PubMed PMID: 15239370.

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