For research use only. Not for therapeutic Use.
Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity[1][2]. Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway[4].
| Catalog Number | I046126 |
| CAS Number | 25368-09-6 |
| Synonyms | (2E,4E,6E,8E,10E,12E,14E)-16-methoxy-2,6,11,15-tetramethyl-16-oxohexadeca-2,4,6,8,10,12,14-heptaenoic acid |
| Molecular Formula | C21H26O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H26O4/c1-16(12-8-14-18(3)20(22)23)10-6-7-11-17(2)13-9-15-19(4)21(24)25-5/h6-15H,1-5H3,(H,22,23)/b7-6+,12-8+,13-9+,16-10+,17-11+,18-14+,19-15+ |
| InChIKey | DGGQUKOLHQXDLV-QTNXRKSWSA-N |
| SMILES | CC(=CC=CC=C(C)C=CC=C(C)C(=O)OC)C=CC=C(C)C(=O)O |
| Reference | [1]. Tseng TH, et al. Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett. 1995 Oct 20;97(1):61-7. [2]. Ahmad AS, et al. Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacol Biochem Behav. 2005 Aug;81(4):805-13. [3]. Nam KN, et al. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. Eur J Pharmacol. 2010 Dec 1;648(1-3):110-6. [4]. Wani A, Al Rihani SB, Sharma A, et al. Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway. Autophagy. 2021;17(11):3813-3832. |
