For research use only. Not for therapeutic Use.
Crotamiton（Cat No.:I003703）is a topical antipruritic and scabicidal agent used to treat skin conditions such as scabies and pruritus. It works by killing the Sarcoptes scabiei mites responsible for scabies and providing relief from itching. Applied as a cream or lotion, Crotamiton soothes irritated skin and reduces discomfort associated with parasitic infestations and other dermatological conditions. Its dual action as a scabicide and antipruritic makes it a versatile treatment option. Crotamiton is well-tolerated and commonly used in both pediatric and adult patients.
| Catalog Number | I003703 |
| CAS Number | 483-63-6 |
| Molecular Formula | C13H17NO |
| Purity | ≥95% |
| Solubility | DMSO:58mg/mL |
| Storage | 2-8°C |
| IUPAC Name | (E)-N-ethyl-N-(2-methylphenyl)but-2-enamide |
| InChI | InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+ |
| InChIKey | DNTGGZPQPQTDQF-XBXARRHUSA-N |
| SMILES | CCN(C1=CC=CC=C1C)C(=O)/C=C/C |
| Reference | </br>1:Topical ivermectin versus crotamiton cream 10% for the treatment of scabies. Goldust M, Rezaee E, Raghiafar R.Int J Dermatol. 2014 Jul;53(7):904-8. doi: 10.1111/ijd.12447. Epub 2014 Jun 5. PMID: 24898622 </br>2:Hailey-Hailey disease diagnosed based on an exacerbation of contact dermatitis with topical crotamiton. Mori N, Mizawa M, Hara H, Norisugi O, Makino T, Nakano H, Sawamura D, Shimizu T.Eur J Dermatol. 2014 Mar-Apr;24(2):263-4. doi: 10.1684/ejd.2014.2288. No abstract available. PMID: 24721608 </br>3:Comparison of oral ivermectin versus crotamiton 10% cream in the treatment of scabies. Goldust M, Rezaee E, Raghifar R.Cutan Ocul Toxicol. 2014 Dec;33(4):333-6. doi: 10.3109/15569527.2013.768258. Epub 2013 Feb 25. PMID: 23431958 </br>4:Treatment of scabies, permethrin 5% cream vs. crotamiton 10% cream. Pourhasan A, Goldust M, Rezaee E.Ann Parasitol. 2013;59(3):143-7. PMID: 24881286 Free Article</br>5:Photocatalytic decomposition of crotamiton over aqueous TiO(2) suspensions: determination of intermediates and the reaction pathway. Fukahori S, Fujiwara T, Ito R, Funamizu N.Chemosphere. 2012 Sep;89(3):213-20. doi: 10.1016/j.chemosphere.2012.04.018. Epub 2012 May 10. PMID: 22578794 </br>6:Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behavior. Sekine R, Satoh T, Takaoka A, Saeki K, Yokozeki H.Exp Dermatol. 2012 Mar;21(3):201-4. doi: 10.1111/j.1600-0625.2011.01433.x. PMID: 22379965 </br>7:Mass balance analysis of triclosan, diethyltoluamide, crotamiton and carbamazepine in sewage treatment plants. Nakada N, Yasojima M, Okayasu Y, Komori K, Suzuki Y.Water Sci Technol. 2010;61(7):1739-47. doi: 10.2166/wst.2010.100. PMID: 20371932 </br>8:Demodex dermatitis: a retrospective analysis of clinical diagnosis and successful treatment with topical crotamiton. Bikowski JB, Del Rosso JQ.J Clin Aesthet Dermatol. 2009 Jan;2(1):20-5. PMID: 20967184 Free PMC Article</br>9:Review: topical permethrin was more effective than topical crotamiton or lindane for scabies. Larson P.Evid Based Nurs. 2008 Apr;11(2):47. doi: 10.1136/ebn.11.2.47. No abstract available. PMID: 18364417 </br>10:Percutaneous absorption of crotamiton in man following single and multiple dosing. Dika E, Tosti A, Goldovsky M, Wester R, Maibach HI.Cutan Ocul Toxicol. 2006;25(3):211-6. PMID: 16980246 |
