For research use only. Not for therapeutic Use.
CRT0105950 is a potent LIMK inhibitor, with IC50s of 0.3 nM and 1 nM for LIMK1 and LIMK2 respectively. CRT0105950 can be used for the research of cancer[1].
| Catalog Number | I025223 |
| CAS Number | 1661845-86-8 |
| Synonyms | 4-[[5-[3-(2-chloro-4-methylphenyl)pyridin-4-yl]-1,3-thiazol-2-yl]amino]phenol |
| Molecular Formula | C21H16ClN3OS |
| Purity | ≥95% |
| InChI | InChI=1S/C21H16ClN3OS/c1-13-2-7-16(19(22)10-13)18-11-23-9-8-17(18)20-12-24-21(27-20)25-14-3-5-15(26)6-4-14/h2-12,26H,1H3,(H,24,25) |
| InChIKey | QYDBOFPHPMYWDO-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1)C2=C(C=CN=C2)C3=CN=C(S3)NC4=CC=C(C=C4)O)Cl |
| Reference | [1]. Mardilovich K, et, al. LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation. Oncotarget. 2015 Nov 17;6(36):38469-86. |
