Cryptotanshinone

• CAT Number: I003313
• CAS Number: 35825-57-1
• Molecular Formula: C₁₉H₂₀O₃
• Molecular Weight: 296.36
• Purity: ≥95%
• Synonyms: (1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[1,2-g][1]benzofuran-10,11-dione
• Target: STAT
• Solubility: DMSO: ≥ 5 mg/mL
• Storage: 3 years -20C powder
• IC50: 4.6 uM [1]
• InChI: InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
• InChIKey: GVKKJJOMQCNPGB-JTQLQIEISA-N
• SMILES: CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C

Cryptotanshinone (Cat No.:I003313) is a natural bioactive compound derived from the roots of Salvia miltiorrhiza. It possesses diverse pharmacological properties, including anti-inflammatory, antioxidant, anticancer, and cardioprotective effects. Cryptotanshinone has demonstrated inhibitory activity against cancer cell growth and proliferation, making it a potential candidate for cancer treatment. It also exhibits anti-inflammatory properties by modulating signaling pathways involved in inflammation.

Reference

1:Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation. Wang Y, Zhou C, Gao H, Li C, Li D, Liu P, Huang M, Shen X, Liu L.Biochem Pharmacol. 2017 May 15. pii: S0006-2952(17)30256-3. doi: 10.1016/j.bcp.2017.05.006. [Epub ahead of print] PMID: 28522406 2:Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation. Lu L, Zhang S, Li C, Zhou C, Li D, Liu P, Huang M, Shen X.Cell Death Dis. 2017 May 11;8(5):e2767. doi: 10.1038/cddis.2017.174. PMID: 28492557 3:Anti-tumor and chemosensitization effects of Cryptotanshinone extracted from Salvia miltiorrhiza Bge. on ovarian cancer cells in vitro. Jiang G, Liu J, Ren B, Zhang L, Owusu L, Liu L, Zhang J, Tang Y, Li W.J Ethnopharmacol. 2017 Apr 26. pii: S0378-8741(17)31102-9. doi: 10.1016/j.jep.2017.04.026. [Epub ahead of print] PMID: 28456578 4:Cryptotanshinone inhibition of mammalian target of rapamycin pathway is dependent on oestrogen receptor alpha in breast cancer. Pan Y, Shi J, Ni W, Liu Y, Wang S, Wang X, Wei Z, Wang A, Chen W, Lu Y.J Cell Mol Med. 2017 Mar 8. doi: 10.1111/jcmm.13135. [Epub ahead of print] PMID: 28272775 Free Article5:Cryptotanshinone potentiates the antitumor effects of doxorubicin on gastric cancer cells via inhibition of STAT3 activity. Wang J, Zhang G, Dai C, Gao X, Wu J, Shen L, Chen Z, Liu P.J Int Med Res. 2017 Feb;45(1):220-230. doi: 10.1177/0300060516685513. Epub 2017 Jan 25. PMID: 28222632 6:Cryptotanshinone enhances the effect of Arsenic trioxide in treating liver cancer cell by inducing apoptosis through downregulating phosphorylated- STAT3 in vitro and in vivo. Shen L, Zhang G, Lou Z, Xu G, Zhang G.BMC Complement Altern Med. 2017 Feb 10;17(1):106. doi: 10.1186/s12906-016-1548-4. PMID: 28187727 Free PMC Article7:Cryptotanshinone Inhibits STAT3 Signaling to Alleviate Cardiac Fibrosis in Type 1-like Diabetic Rats. Lo SH, Hsu CT, Niu HS, Niu CS, Cheng JT, Chen ZC.Phytother Res. 2017 Apr;31(4):638-646. doi: 10.1002/ptr.5777. Epub 2017 Feb 8. PMID: 28176375 8:Cryptotanshinone Regulates Androgen Synthesis through the ERK/c-Fos/CYP17 Pathway in Porcine Granulosa Cells. Ye D, Li M, Zhang Y, Wang X, Liu H, Wu W, Ma W, Quan K, Ng EH, Wu X, Lai M, Ma H.Evid Based Complement Alternat Med. 2017;2017:5985703. doi: 10.1155/2017/5985703. Epub 2017 Jan 12. PMID: 28167972 Free PMC Article9:Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells. Chen W, Pan Y, Wang S, Liu Y, Chen G, Zhou L, Ni W, Wang A, Lu Y.BMC Cancer. 2017 Jan 7;17(1):34. doi: 10.1186/s12885-016-3038-y. PMID: 28061838 Free PMC Article10:Cryptotanshinone inhibits VEGF-induced angiogenesis by targeting the VEGFR2 signaling pathway. Xu X, Wu L, Zhou X, Zhou N, Zhuang Q, Yang J, Dai J, Wang H, Chen S, Mao W.Microvasc Res. 2017 May;111:25-31. doi: 10.1016/j.mvr.2016.12.011. Epub 2016 Dec 28. PMID: 28040437