For research use only. Not for therapeutic Use.
TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects (IC50 values 4.3 µM, 11.5 µM, and 4.6 µM for inhibition of proliferation of breast cancer MDA-MB-231, human lung cancer A549 and human cervical cancer HeLa cell lines, respectively). CS1 functions as a Topo II poison to stabilize Topo II/DNA complex, which leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis, and is 6–10-fold less cytotoxic against HL7702 and HUVEC cells compared with etoposide.
| Catalog Number | I025236 |
| CAS Number | 1448009-94-6 |
| Molecular Formula | C16H12O3 |
| Purity | ≥95% |
| IUPAC Name | 4-(6-hydroxynaphthalen-2-yl)benzene-1,2-diol |
| InChI | InChI=1S/C16H12O3/c17-14-5-3-11-7-10(1-2-12(11)8-14)13-4-6-15(18)16(19)9-13/h1-9,17-19H |
| SMILES | C1=CC2=C(C=CC(=C2)O)C=C1C3=CC(=C(C=C3)O)O |
| Reference | W. Chen et al. Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents. Eur J Med Chem. 2014 Oct 30;86:782-96.
Y. Shen et al. CS1 is a novel topoisomerase IIα inhibitor with favorable drug resistance profiles. Biochem Biophys Res Commun. 2014 Oct 24;453(3):302-8. |
