For research use only. Not for therapeutic Use.
CS587 is a specific inhibitor of CaMK1D with neurocytotoxicity at 10 μM. CS587 modulates the sensitivity of neuronal cells to Aβ oligomer toxicity[1].
| Catalog Number | I041096 |
| CAS Number | 2388506-69-0 |
| Synonyms | 2-[(3S)-3-aminopiperidin-1-yl]-4-[3,5-bis(2-cyanopropan-2-yl)anilino]pyrimidine-5-carboxamide |
| Molecular Formula | C24H30N8O |
| Purity | ≥95% |
| InChI | InChI=1S/C24H30N8O/c1-23(2,13-25)15-8-16(24(3,4)14-26)10-18(9-15)30-21-19(20(28)33)11-29-22(31-21)32-7-5-6-17(27)12-32/h8-11,17H,5-7,12,27H2,1-4H3,(H2,28,33)(H,29,30,31)/t17-/m0/s1 |
| InChIKey | RJTDRNOTQRMDCY-KRWDZBQOSA-N |
| SMILES | CC(C)(C#N)C1=CC(=CC(=C1)NC2=NC(=NC=C2C(=O)N)N3CCCC(C3)N)C(C)(C)C#N |
| Reference | [1]. Grant P, et al. Effects of Specific Inhibitors for CaMK1D on a Primary Neuron Model for Alzheimer’s Disease. Molecules. 2021 Dec 18;26(24):7669. |
