CSF1R-IN-1

• CAT Number: I019641
• CAS Number: 2095849-04-8
• Molecular Formula: C₂₅H₂₀F₃N₅O₂
• Molecular Weight: 479.45
• Purity: ≥95%
• Target: c-Fms
• IUPAC Name: 5-(1-methylpyrazol-4-yl)-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]pyridine-3-carboxamide
• InChI: InChI=1S/C25H20F3N5O2/c1-15-6-7-21(31-23(34)16-4-3-5-20(9-16)25(26,27)28)10-22(15)32-24(35)18-8-17(11-29-12-18)19-13-30-33(2)14-19/h3-14H,1-2H3,(H,31,34)(H,32,35)
• InChIKey: BMEXIUCHJUGPRB-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)NC(=O)C3=CN=CC(=C3)C4=CN(N=C4)C

CSF1R-IN-1（Cat No.:I019641）is a small molecule inhibitor that targets the colony-stimulating factor 1 receptor (CSF1R), a key receptor involved in the regulation of macrophage differentiation, survival, and function. By inhibiting CSF1R, CSF1R-IN-1 can modulate the immune response, making it a potential therapeutic candidate for treating diseases driven by macrophage activity, such as cancer, autoimmune disorders, and chronic inflammation. Preclinical studies have shown that CSF1R-IN-1 can reduce macrophage infiltration in tumors, potentially enhancing the efficacy of other cancer therapies. Further clinical trials are required to assess its safety and therapeutic potential.

Reference

[1]. Ramachandran SA, et al. Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors. Bioorg Med Chem Lett. 2017 May 15;27(10):2153-2160.