CSF1R-IN-1

• CAT Number: I019641
• CAS Number: 2095849-04-8
• Molecular Formula: C₂₅H₂₀F₃N₅O₂
• Molecular Weight: 479.45
• Purity: ≥95%
• Target: c-Fms

CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM.CSF1R is thought to play an important role in recruitment and differentiation of tumor-associated macrophages (TAMs). CSF1R-IN-1 (compound 22) shows good intestinal permeability in a Caco2 assay[1].CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept.[1].

Reference

[1]. Ramachandran SA, et al. Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors. Bioorg Med Chem Lett. 2017 May 15;27(10):2153-2160.