CSF1R-IN-12

• CAT Number: I043659
• CAS Number: 2361556-35-4
• Molecular Formula: C21H17F3N4O
• Molecular Weight: 398.38
• Purity: ≥95%
• Synonyms: 4-[4-methyl-6-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]pyridin-3-yl]-2,3-dihydroisoindol-1-one
• InChI: InChI=1S/C21H17F3N4O/c1-12-7-19(26-9-13-5-6-18(25-8-13)21(22,23)24)27-10-16(12)14-3-2-4-15-17(14)11-28-20(15)29/h2-8,10H,9,11H2,1H3,(H,26,27)(H,28,29)
• InChIKey: NUASBLXKMUYBJO-UHFFFAOYSA-N
• SMILES: CC1=CC(=NC=C1C2=C3CNC(=O)C3=CC=C2)NCC4=CN=C(C=C4)C(F)(F)F

CSF1R-IN-12 is a potent inhibitor of CSF1R. Colony stimulating factor 1 (CSF-1, also known as macrophage colony stimulating factor, M-CSF) is an important growth factor that controls bone marrow progenitor cells, monocytes, macrophages, and giants. CSF1R-IN-12 has the potential for the research of cancer diseases (extracted from patent WO2019134661A1, compound 1)[1].

Reference

[1]. Wenyun Qian, et al. Isoindolinone and derivative thereof as csf-1r inhibitor. Patent WO2019134661A1.