CSN5i-3

• CAT Number: I020086
• CAS Number: 2375740-98-8
• Molecular Formula: C₂₈H₂₉F₂N₅O₂
• Molecular Weight: 505.56
• Purity: ≥95%

CSN5i-3 (CAT: I020086) is a selective inhibitor of the COP9 signalosome subunit 5 (CSN5), also known as COPS5 or Jab1. The COP9 signalosome is a multi-subunit protein complex involved in the regulation of various cellular processes, including protein degradation, cell cycle progression, and DNA repair. CSN5 is a key component of the COP9 signalosome and plays a crucial role in its enzymatic activity. CSN5i-3 specifically targets CSN5 and inhibits its function, leading to disruption of the COP9 signalosome activity. By modulating the activity of CSN5, CSN5i-3 can potentially impact cellular processes that rely on the COP9 signalosome, making it a valuable tool in research for studying the biological functions of this complex and exploring its therapeutic potential.

Reference

[1]. Schlierf A, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016 Oct 24;7:13166.