CSNK1-IN-1

• CAT Number: I042313
• CAS Number: 2468784-55-4
• Molecular Formula: C29H26F3N5O2
• Molecular Weight: 533.54
• Purity: ≥95%
• Synonyms: (2R)-N-[4-(3-anilino-5-methyl-4-oxo-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-2-yl)pyridin-2-yl]-4,4-difluoro-2-(4-fluorophenyl)butanamide
• InChI: InChI=1S/C29H26F3N5O2/c1-37-14-12-22-25(29(37)39)27(34-20-5-3-2-4-6-20)26(35-22)18-11-13-33-24(15-18)36-28(38)21(16-23(31)32)17-7-9-19(30)10-8-17/h2-11,13,15,21,23,34-35H,12,14,16H2,1H3,(H,33,36,38)/t21-/m1/s1
• InChIKey: IKATWWUGCJFQJV-OAQYLSRUSA-N
• SMILES: CN1CCC2=C(C1=O)C(=C(N2)C3=CC(=NC=C3)NC(=O)C(CC(F)F)C4=CC=C(C=C4)F)NC5=CC=CC=C5

CSNK1-IN-1 is a CSNK1A1 inhibitor. CSNK1-IN-1 has inhibitory activity for CSNK1A1 kinase with IC50 values of 21 μM. CSNK1-IN-1 can be used for the research of proliferative disorders[1].
CSNK1-IN-1 has inhibitory activity for CSNK1A1, CSNK1D and CSNK1A1 (in high ATP) with IC50 values of 21μM, 29.7μM and 1.5 nM, respectively[1].
CSNK1-IN-1 shows low inhibition for wild type-EGFR kinase with an IC50 value of ＞20 nM[1].

Reference

[1]. Volker Schulze, et al. 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as csnk1 inhibitors. Patent. WO2020161257 A1.