CSNK1-IN-2

• CAT Number: I042312
• CAS Number: 2468783-76-6
• Molecular Formula: C28H26FN5O2
• Molecular Weight: 483.54
• Purity: ≥95%
• Synonyms: (2R)-N-[4-(3-anilino-5-methyl-4-oxo-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-2-yl)pyridin-2-yl]-2-(4-fluorophenyl)propanamide
• InChI: InChI=1S/C28H26FN5O2/c1-17(18-8-10-20(29)11-9-18)27(35)33-23-16-19(12-14-30-23)25-26(31-21-6-4-3-5-7-21)24-22(32-25)13-15-34(2)28(24)36/h3-12,14,16-17,31-32H,13,15H2,1-2H3,(H,30,33,35)/t17-/m1/s1
• InChIKey: UYAQWCZWVIFRCN-QGZVFWFLSA-N
• SMILES: CC(C1=CC=C(C=C1)F)C(=O)NC2=NC=CC(=C2)C3=C(C4=C(N3)CCN(C4=O)C)NC5=CC=CC=C5

CSNK1-IN-2 is a CSNK1A1 inhibitor. CSNK1-IN-1 has inhibitory activity for CSNK1A1 kinase with IC50 values of 2.52 μM. CSNK1-IN-2 can be used for the research of proliferative disorders[1].
CSNK1-IN-2 (example 7) has inhibitory activity for CSNK1A1, CSNK1D and CSNK1A1 (in high ATP) with IC50 values of 2.52 μM, 8.48 μM and 107 μM, respectively[1].
CSNK1-IN-2 shows inhibition for wild type-EGFR kinase with an IC50 value of 2.74 nM[1].

Reference

[1]. Volker Schulze, et al. 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as csnk1 inhibitors. Patent. WO2020161257 A1.