For research use only. Not for therapeutic Use.
CT-053 Toluene Sulfonate (CAT: I006306), also referred to as DE-120, is a promising inhibitor with dual activity against vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF). This compound holds potential for the treatment of wet age-related macular degeneration (AMD), a common eye disorder characterized by abnormal blood vessel growth beneath the retina. By targeting both VEGF and PDGF pathways, CT-053 aims to mitigate the pathological angiogenesis and vascular leakage associated with wet AMD, offering a novel therapeutic approach for managing this debilitating condition.
| Catalog Number | I006306 |
| CAS Number | 1394820-77-9 |
| Synonyms | CT-053; DE-120; CT053; DE120; CT 053; DE 120;N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 4-methylbenzenesulfonate |
| Molecular Formula | C38H37FN4O8S |
| Purity | ≥95% |
| Target | TAM Receptor |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| InChI | InChI=1S/C31H29FN4O5.C7H8O3S/c1-19-28(30(38)36(35(19)4)21-8-6-5-7-9-21)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(11-12-23(25)26)40-18-31(2,3)39;1-6-2-4-7(5-3-6)11(8,9)10/h5-17,39H,18H2,1-4H3,(H,34,37);2-5H,1H3,(H,8,9,10) |
| InChIKey | NAUYISNCVNUUDK-UHFFFAOYSA-N |
| SMILES | O=C(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)NC3=CC=C(OC4=CC=NC5=CC(OCC(C)(O)C)=CC=C45)C(F)=C3.CC6=CC=C(S(=O)(O)=O)C=C6 |
| Reference | </br>1:Crystal structure of octa-μ3-selenido-(p-toluene-sulfonato-κO)penta-kis-(tri-ethyl-phosphane-κP)-octa-hedro-hexa-rhenium(III) p-toluene-sulfonate di-chloro-methane disolvate. Edwards JA, McDonald R, Szczepura LF.Acta Crystallogr E Crystallogr Commun. 2015 Aug 6;71(Pt 9):m158-9. doi: 10.1107/S2056989015014334. eCollection 2015 Sep 1. PMID: 26396864 Free PMC Article</br>2:Crystal structure of 2,4-di-amino-6-oxo-3,6-di-hydro-pyrimidin-1-ium p-toluene-sulfonate. Mamallan K, Tagore SS, Gomathi S, Sethuraman V.Acta Crystallogr E Crystallogr Commun. 2015 Apr 11;71(Pt 5):476-8. doi: 10.1107/S2056989015006787. eCollection 2015 May 1. PMID: 25995859 Free PMC Article</br>3:Electrical conductivity of poly(3,4-ethylenedioxythiophene):p-toluene sulfonate films hybridized with reduced graphene oxide. Lee JT, Choi SH, Kim JY.Nanoscale Res Lett. 2014 Nov 29;9(1):644. doi: 10.1186/1556-276X-9-644. eCollection 2014. PMID: 25520593 Free PMC Article</br>4:Synthesis, growth, structure and spectroscopic characterization of a new organic nonlinear optical hydrogen bonding complex crystal: 3-carboxyl anilinium p-toluene sulfonate. Selvakumar E, Anandha babu G, Ramasamy P, Rajnikant, Uma Devi T, Meenakshi R, Chandramohan A.Spectrochim Acta A Mol Biomol Spectrosc. 2014 May 5;125:114-9. doi: 10.1016/j.saa.2014.01.035. Epub 2014 Jan 30. PMID: 24531540 </br>5:3-Hy-droxy-anilinium p-toluene-sulfonate. Bincy IP, Gopalakrishnan R.Acta Crystallogr Sect E Struct Rep Online. 2013 Jul 20;69(Pt 8):o1277. doi: 10.1107/S1600536813018692. eCollection 2013. PMID: 24109359 Free PMC Article</br>6:l-Histidinium p-toluene-sulfonate. Muralidharan S, Nagapandiselvi P, Srinivasan T, Gopalakrishnan R, Velmurugan D.Acta Crystallogr Sect E Struct Rep Online. 2013 Apr 30;69(Pt 5):o804. doi: 10.1107/S1600536813011161. Print 2013 May 1. PMID: 23723944 Free PMC Article</br>7:Cinnarizinium bis-(p-toluene-sulfonate) dihydrate. Kavitha CN, Butcher RJ, Jasinski JP, Yathirajan HS, Dayananda AS.Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 6;69(Pt 4):o485-6. doi: 10.1107/S1600536813003991. Print 2013 Apr 1. PMID: 23634038 Free PMC Article</br>8:Preparation of Pt/polypyrrole-para toluene sulfonate hydrogen peroxide sensitive electrode for the utilizing as a biosensor. Çete S, Bal Ö.Artif Cells Nanomed Biotechnol. 2013 Dec;41(6):414-20. doi: 10.3109/21691401.2012.759121. Epub 2013 Jan 22. PMID: 23336613 </br>9:4-Nitro-anilinium p-toluene-sulfonate. Sivakumar PK, Krishnakumar M, Kanagadurai R, Chakkaravarthi G, Mohankumar R.Acta Crystallogr Sect E Struct Rep Online. 2012 Oct 1;68(Pt 10):o3059. doi: 10.1107/S1600536812040664. Epub 2012 Sep 29. PMID: 23125819 Free PMC Article</br>10:2-Hy-droxy-pyridinium p-toluene-sulfonate. Jin Y.Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1669. doi: 10.1107/S1600536812019873. Epub 2012 May 12. PMID: 22719464 Free PMC Article |
