CT 32228

• CAT Number: I025245
• CAS Number: 521064-34-6
• Molecular Formula: C16H13BrClN5
• Molecular Weight: 390.669
• Purity: 98%
• Synonyms: CT 32228; CT-32228; CT32228
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 1,3,5-Triazine-2,4-diamine, N-(4-bromophenyl)-6-(5-chloro-2-methylphenyl)-
• InChI: InChI=1S/C16H13BrClN5/c1-9-2-5-11(18)8-13(9)14-21-15(19)23-16(22-14)20-12-6-3-10(17)4-7-12/h2-8H,1H3,(H3,19,20,21,22,23)
• InChIKey: NUPGPJBRKLLVNK-UHFFFAOYSA-N
• SMILES: NC1=NC(C2=CC(Cl)=CC=C2C)=NC(NC3=CC=C(Br)C=C3)=N1

CT 32228 is the inactive isomer of CT-32228 used as a control.

Reference

1: Douvas MG, Hogan KN, Ji Y, Hollenback D, Bonham L, Singer JW, Mitchell BS. Effect of lysophosphatidic acid acyltransferase-beta inhibition in acute leukemia. Leuk Res. 2006 Aug;30(8):1027-36. doi: 10.1016/j.leukres.2005.11.018. Epub 2006 Feb 20. PMID: 16488473.
2: Pagel JM, Laugen C, Bonham L, Hackman RC, Hockenbery DM, Bhatt R, Hollenback D, Carew H, Singer JW, Press OW. Induction of apoptosis using inhibitors of lysophosphatidic acid acyltransferase-beta and anti-CD20 monoclonal antibodies for treatment of human non-Hodgkin’s lymphomas. Clin Cancer Res. 2005 Jul 1;11(13):4857-66. doi: 10.1158/1078-0432.CCR-04-2352. PMID: 16000584.
3: Bonham L, Leung DW, White T, Hollenback D, Klein P, Tulinsky J, Coon M, de Vries P, Singer JW. Lysophosphatidic acid acyltransferase-beta: a novel target for induction of tumour cell apoptosis. Expert Opin Ther Targets. 2003 Oct;7(5):643-61. doi: 10.1517/14728222.7.5.643. PMID: 14498826.
4: Springett GM, Bonham L, Hummer A, Linkov I, Misra D, Ma C, Pezzoni G, Di Giovine S, Singer J, Kawasaki H, Spriggs D, Soslow R, Dupont J. Lysophosphatidic acid acyltransferase-beta is a prognostic marker and therapeutic target in gynecologic malignancies. Cancer Res. 2005 Oct 15;65(20):9415-25. doi: 10.1158/0008-5472.CAN-05-0516. Erratum in: Cancer Res. 2005 Dec 15;65(24):11785. PMID: 16230405.
5: La Rosée P, Jia T, Demehri S, Härtel N, de Vries P, Bonham L, Hollenback D, Singer JW, Melo JV, Druker BJ, Deininger MW. Antileukemic activity of lysophosphatidic acid acyltransferase-beta inhibitor CT32228 in chronic myelogenous leukemia sensitive and resistant to imatinib. Clin Cancer Res. 2006 Nov 1;12(21):6540-6. doi: 10.1158/1078-0432.CCR-06-0140. PMID: 17085669.