CTPI-2

• CAT Number: I025251
• CAS Number: 68003-38-3
• Molecular Formula: C23H25N3O3
• Molecular Weight: 391.47
• Purity: 98%
• Synonyms: ABD-7; ABD 7; ABD7; RAS inhibitor Abd-7; CTPI-2; CTPI 2; CTPI2; D1W
• Target: Mitochondrial Metabolism
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 6-(2,3-Dihydro-1,4-benzodioxin-5-yl)-N-[4-[(dimethylamino)methyl]phenyl]-2-methoxypyridin-3-amine
• InChI: InChI=1S/C23H25N3O3/c1-26(2)15-16-7-9-17(10-8-16)24-20-12-11-19(25-23(20)27-3)18-5-4-6-21-22(18)29-14-13-28-21/h4-12,24H,13-15H2,1-3H3
• InChIKey: MJHHFDJNRRCUOB-UHFFFAOYSA-N
• SMILES: COC1=NC(C2=C3OCCOC3=CC=C2)=CC=C1NC4=CC=C(CN(C)C)C=C4

CTPI-2 (CAT: I025251), also referred to as ABD7, serves as a specific inhibitor of SLC25A1, a mitochondrial citrate transporter. By targeting SLC25A1, CTPI-2 disrupts the transport of citrate across the mitochondrial membrane, affecting citrate metabolism and related cellular processes. This inhibition can have diverse implications, potentially influencing cellular energy production, lipid synthesis, and other metabolic pathways reliant on citrate availability.

Reference

1: O’Bryan JP. Pharmacological targeting of RAS: Recent success with direct inhibitors. Pharmacol Res. 2019 Jan;139:503-511. doi: 10.1016/j.phrs.2018.10.021. Epub 2018 Oct 23. Review. PubMed PMID: 30366101; PubMed Central PMCID: PMC6360110.