CU-CPD107

• CAT Number: I047229
• CAS Number: 2573912-32-8
• Molecular Formula: C16H21IN2O2
• Molecular Weight: 400.26
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CCOCC1=NC(=C([N]1CC(C)(C)O)C2=CC=CC=C2)I

CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. In the presence of R848, CU-CPD107 acts as a TLR8 signaling inhibitor (IC50=13.7 μM). In the presence of ssRNA, CU-CPD107 shows synergistic agonist activities, while CU-CPD107 alone is unable to influence TLR8 signaling.

Reference

[1] Yang Y, et al. Nat Commun. 2021 Jul 16;12(1):4351.