CU-CPT 4a

• CAT Number: I011048
• CAS Number: 1279713-77-7
• Molecular Formula: C18H13ClFNO3S
• Molecular Weight: 377.82
• Purity: ≥95%
• Synonyms: (2R)-2-[(3-chloro-6-fluoro-1-benzothiophene-2-carbonyl)amino]-3-phenylpropanoic acid
• InChI: InChI=1S/C18H13ClFNO3S/c19-15-12-7-6-11(20)9-14(12)25-16(15)17(22)21-13(18(23)24)8-10-4-2-1-3-5-10/h1-7,9,13H,8H2,(H,21,22)(H,23,24)/t13-/m1/s1
• InChIKey: IAASQMCXDRISAV-CYBMUJFWSA-N
• SMILES: C1=CC=C(C=C1)CC(C(=O)O)NC(=O)C2=C(C3=C(S2)C=C(C=C3)F)Cl

CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β[1].
CU-CPT 4a shows dose-dependent inhibitory effects blocking Poly (I:C)-induced TLR3 activation with an IC50 of 3.44 µM[1].
CU-CPT 4a competes with dsRNA for binding to TLR3 with a Ki of 2.96 µM[1].

Reference

[1]. Yibo Wang, et al. Small-Molecule Modulators of Toll-like Receptors. Acc Chem Res. 2020 May 19;53(5):1046-1055.
 [Content Brief]