CU-CPT9b

For research use only. Not for therapeutic Use.

  • CAT Number: I019895
  • CAS Number: 2162962-69-6
  • Molecular Formula: C₁₆H₁₃NO₂
  • Molecular Weight: 251.28
  • Purity: ≥95%
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CU-CPT9b(Cat No.:I019895) is a potent and selective antagonist of Toll-like receptor 8 (TLR8), a member of the Toll-like receptor family involved in innate immune responses. With an IC50 of 0.7 nM, CU-CPT9b effectively inhibits TLR8 signaling. It exhibits high binding affinity to TLR8, with a dissociation constant (Kd) of 21 nM, indicating strong interaction with the receptor. By specifically targeting TLR8, CU-CPT9b has the potential to modulate immune responses mediated by TLR8, offering opportunities for therapeutic interventions in various inflammatory and immune-related conditions.


Catalog Number I019895
CAS Number 2162962-69-6
Molecular Formula C₁₆H₁₃NO₂
Purity ≥95%
Target Toll-like Receptor (TLR)
Storage Store at -20°C
IUPAC Name 4-(4-hydroxy-3-methylphenyl)quinolin-7-ol
InChI InChI=1S/C16H13NO2/c1-10-8-11(2-5-16(10)19)13-6-7-17-15-9-12(18)3-4-14(13)15/h2-9,18-19H,1H3
InChIKey QXFYDRYRLOHSBD-UHFFFAOYSA-N
SMILES CC1=C(C=CC(=C1)C2=C3C=CC(=CC3=NC=C2)O)O
Reference

[1]. Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14(1):58-64.

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