For research use only. Not for therapeutic Use.
CU-CPT9b(Cat No.:I019895) is a potent and selective antagonist of Toll-like receptor 8 (TLR8), a member of the Toll-like receptor family involved in innate immune responses. With an IC50 of 0.7 nM, CU-CPT9b effectively inhibits TLR8 signaling. It exhibits high binding affinity to TLR8, with a dissociation constant (Kd) of 21 nM, indicating strong interaction with the receptor. By specifically targeting TLR8, CU-CPT9b has the potential to modulate immune responses mediated by TLR8, offering opportunities for therapeutic interventions in various inflammatory and immune-related conditions.
Catalog Number | I019895 |
CAS Number | 2162962-69-6 |
Molecular Formula | C₁₆H₁₃NO₂ |
Purity | ≥95% |
Target | Toll-like Receptor (TLR) |
Storage | Store at -20°C |
IUPAC Name | 4-(4-hydroxy-3-methylphenyl)quinolin-7-ol |
InChI | InChI=1S/C16H13NO2/c1-10-8-11(2-5-16(10)19)13-6-7-17-15-9-12(18)3-4-14(13)15/h2-9,18-19H,1H3 |
InChIKey | QXFYDRYRLOHSBD-UHFFFAOYSA-N |
SMILES | CC1=C(C=CC(=C1)C2=C3C=CC(=CC3=NC=C2)O)O |
Reference | [1]. Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14(1):58-64. |