Cucurbitacin I

• CAT Number: I000030
• CAS Number: 2222-07-3
• Molecular Formula: C30H42O7
• Molecular Weight: 514.70
• Purity: ≥95%
• Synonyms: (8S,9R,10R,13R,14S,16R,17R)-17-[(E,2R)-2,6-dihydroxy-6-methyl-3-oxohept-4-en-2-yl]-2,16-dihydroxy-4,4,9,13,14-pentamethyl-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthrene-3,11-dione
• Target: Stem Cell/Wnt
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C30H42O7/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3/b12-11+/t17-,19-,20+,23+,27+,28-,29+,30+/m1/s1
• InChIKey: NISPVUDLMHQFRQ-MKIKIEMVSA-N
• SMILES: C[C@@]12C[C@H]([C@@H]([C@]1(CC(=O)[C@@]3([C@H]2CC=C4[C@H]3C=C(C(=O)C4(C)C)O)C)C)[C@](C)(C(=O)/C=C/C(C)(C)O)O)O

Cucurbitacin I（Cat No.:I000030）is a bioactive compound derived from plants in the Cucurbitaceae family, including cucumbers and gourds. It is known for its potent anti-inflammatory, anticancer, and antiproliferative properties. Cucurbitacin I works by inhibiting key signaling pathways involved in cell growth, survival, and inflammation, particularly the JAK/STAT and MAPK pathways. Its anticancer activity is attributed to its ability to suppress tumor cell proliferation and induce apoptosis. Cucurbitacin I has been studied in preclinical models for the treatment of various cancers, autoimmune diseases, and inflammatory conditions, though further clinical development is needed.

Reference

[1]. Song J, et al. Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer. Oncol Rep. 2015 Apr;33(4):1867-71.

[2]. Jeong MH, et al. Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings. PLoS One. 2015 Aug 21;10(8):e0136236.