Cu(II)GTSM

• CAT Number: I044418
• CAS Number: 68341-14-0
• Molecular Formula: C6H10CuN6S2
• Molecular Weight: 293.86
• Purity: ≥95%

Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu(II)GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu(II)GTSM also decreases the abundance of Amyloid-β trimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent[1][2].
Cu(II)GTSM induces GSK3β phosphorylation at serine-9 (ser9) via its upstream kinase, protein kinase B (Akt), and aslo increases the phosphorylation of the associated extracellular signal-related kinase 1/2 (ERK1/2) in SH-SY5Y cells.
Tau phosphorylation at ser404 was decreased in CuII(gtsm)-treated cells by 64%[2].
Cu(II)GTSM decreases brain Aβ trimer levels in AD mice, and can reverse cognitive deficits in APP/PS1 transgenic AD mice[2].

Reference

[1]. Andres SA, et al. Synthesis, Characterization, and Biological Activity of Hybrid Thiosemicarbazone-Alkylthiocarbamate Metal Complexes. Inorg Chem. 2020;59(7):4924-4935.
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[2]. Crouch PJ, et al. Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation. Proc Natl Acad Sci U S A. 2009;106(2):381-386.
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