CUR-61414

• CAT Number: R009173
• CAS Number: 334998-36-6
• Molecular Formula: C31H42N4O5
• Molecular Weight: 550.70
• Purity: ≥95%
• Synonyms: N-[(3S,5S)-1-(1,3-Benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide
• Target: Apoptosis
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-[(3S,5S)-1-(1,3-benzodioxol-5-ylmethyl)-5-(piperazine-1-carbonyl)pyrrolidin-3-yl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide
• InChI: InChI=1S/C31H42N4O5/c1-31(2,3)17-29(36)35(19-22-6-5-7-25(14-22)38-4)24-16-26(30(37)33-12-10-32-11-13-33)34(20-24)18-23-8-9-27-28(15-23)40-21-39-27/h5-9,14-15,24,26,32H,10-13,16-21H2,1-4H3/t24-,26-/m0/s1
• InChIKey: WPHXYKUPFJRJDK-AHWVRZQESA-N
• SMILES: CC(C)(C)CC(=O)N(CC1=CC(=CC=C1)OC)C2CC(N(C2)CC3=CC4=C(C=C3)OCO4)C(=O)N5CCNCC5

CUR-61414 is a selective inhibitor of the nuclear factor kappa B (NF-κB) signaling pathway, specifically targeting the IκB kinase (IKK) complex. It has shown potential in modulating inflammatory responses, inhibiting tumor progression, and enhancing the immune response. This compound is being investigated for its therapeutic applications in cancer, autoimmune diseases, and chronic inflammation. By selectively targeting NF-κB, CUR-61414 aims to provide a novel approach for managing various NF-κB-driven pathologies.