For research use only. Not for therapeutic Use.
Small molecule upregulator of the Survival of Motor Neuron protein (SMN; EC50 value 18 μM in SMA patient fibroblast cells); a tool compound that revealed that increasing Ras signaling upregulates SMN protein levels by increased phosphorylation of Erk, an important member of the Ras-Raf-MEK signaling cascade.
KEYWORDS: Cuspin 1 | Supplier | SMN upregulator | Axon Medchem | Axon 2438 | Cuspin1 | CAS [337932-29-3] | GTP | RAS | RAF | MEK | ERK | Activator | Enzymes | Survival of Motor Neuron Protein | SMN | SMA | fibroblasts | Spliceosome | RNP
| Catalog Number | R065808 |
| CAS Number | 337932-29-3 |
| Molecular Formula | C13H10BrNO |
| Purity | ≥95% |
| IUPAC Name | (5-bromopyridin-3-yl)-(4-methylphenyl)methanone |
| InChI | InChI=1S/C13H10BrNO/c1-9-2-4-10(5-3-9)13(16)11-6-12(14)8-15-7-11/h2-8H,1H3 |
| SMILES | CC1=CC=C(C=C1)C(=O)C2=CC(=CN=C2)Br |
| Reference | R.R. Letso et al. Small molecule screen reveals regulation of survival motor neuron protein abundance by Ras proteins. ACS Chem Biol. 2013 May 17;8(5):914-22.
R.R. Letso. Investigating neurodegenerative diseases with small molecule modulators. Thesis, Columbia University, 2011 |
