For research use only. Not for therapeutic Use.
CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively[1].
CV1808 demonstrates an inhibitory effect on anti-IgE-induced activation at 100 μM[1].
In the presence of Forskolin (1 μM in PC12 cells; 10 μM in Jurkat cells) the EC50 value for CV1808 is 2 μM[2].
Single afferent arterioles of Sprague-Dawley rats are visualized and superfused with solutions containing CV1808 (CV-1808). Superfusion with CV1808 (0.002-2 μM) dilates afferent arterioles[3].
| Catalog Number | R003224 |
| CAS Number | 53296-10-9 |
| Synonyms | (2R,3R,4S,5R)-2-(6-amino-2-anilinopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
| Molecular Formula | C16H18N6O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H18N6O4/c17-13-10-14(21-16(20-13)19-8-4-2-1-3-5-8)22(7-18-10)15-12(25)11(24)9(6-23)26-15/h1-5,7,9,11-12,15,23-25H,6H2,(H3,17,19,20,21)/t9-,11-,12-,15-/m1/s1 |
| InChIKey | SCNILGOVBBRMBK-SDBHATRESA-N |
| SMILES | C1=CC=C(C=C1)NC2=NC(=C3C(=N2)N(C=N3)C4C(C(C(O4)CO)O)O)N |
| Reference | [1]. K H Yip, et al. Reciprocal modulation of anti-IgE induced histamine release from human mast cells by A₁ and A(2B) adenosine receptors. Br J Pharmacol. 2011 Sep;164(2b):807-19. [2]. I van der Ploeg,et al.Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists. Naunyn Schmiedebergs Arch Pharmacol.1996 Feb;353(3):250-60. [3]. Ming-Guo Feng, et al. Afferent arteriolar vasodilator effect of adenosine predominantly involves adenosine A2B receptor activation. Am J Physiol Renal Physiol. 2010 Aug;299(2):F310-5. |
