For research use only. Not for therapeutic Use.
CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC50 value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) permeability[1].
CVN636 (0.3-3 mg/kg; p.o.) reduces ethanol self-administration in msP rats[1].
| Catalog Number | I041135 |
| CAS Number | 2226732-62-1 |
| Synonyms | (2S)-2-(4-fluorophenyl)-N-[(3S,4S)-4-methylsulfonyl-3,4-dihydro-2H-chromen-3-yl]propanamide |
| Molecular Formula | C19H20FNO4S |
| Purity | ≥95% |
| InChI | InChI=1S/C19H20FNO4S/c1-12(13-7-9-14(20)10-8-13)19(22)21-16-11-25-17-6-4-3-5-15(17)18(16)26(2,23)24/h3-10,12,16,18H,11H2,1-2H3,(H,21,22)/t12-,16-,18-/m0/s1 |
| InChIKey | DKLUNKKXISSMIY-IWEFOYFVSA-N |
| SMILES | CC(C1=CC=C(C=C1)F)C(=O)NC2COC3=CC=CC=C3C2S(=O)(=O)C |
| Reference | [1]. Ayscough AP, et, al. Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449. [2]. Dickson L, et, al. Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449. |
