For research use only. Not for therapeutic Use.
CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer[1].
CVT-11127 (1 µM, 48 h) shows antiproliferation activity in H460 cells[1].
CVT-11127 (1 µM, 48 h) decreases the the population of cells in S-phase by 75%[1].
CVT-11127 (1 µM, 48 h) induces apoposis in H460 cells[1].
CVT-11127 (1, 2 µM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells[1].
| Catalog Number | R040312 |
| CAS Number | 1018674-83-3 |
| Synonyms | N-[2-[6-[(3,4-dichlorophenyl)methylamino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide |
| Molecular Formula | C25H23Cl2N5O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H23Cl2N5O3/c1-15(33)28-11-12-32-24-21(30-23(25(32)34)17-4-6-18(35-2)7-5-17)9-10-22(31-24)29-14-16-3-8-19(26)20(27)13-16/h3-10,13H,11-12,14H2,1-2H3,(H,28,33)(H,29,31) |
| InChIKey | PVTIQVJHZDSETN-UHFFFAOYSA-N |
| SMILES | CC(=O)NCCN1C2=C(C=CC(=N2)NCC3=CC(=C(C=C3)Cl)Cl)N=C(C1=O)C4=CC=C(C=C4)OC |
| Reference | [1]. Hess D,et al. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One. 2010; 5(6):e11394. |
