For research use only. Not for therapeutic Use.
Orally available, potent and selective casein kinase 2 (CK2) inhibitor
| Catalog Number | I047582 |
| CAS Number | 2108312-01-0 |
| Molecular Formula | C19H12ClN3O2.HCl |
| Purity | ≥95% |
| IUPAC Name | 5-(3-chloroanilino)benzo[c][2,6]naphthyridine-8-carboxylic acid;hydrochloride |
| InChI | InChI=1S/C19H12ClN3O2.ClH/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18;/h1-10H,(H,22,23)(H,24,25);1H |
| SMILES | C1=CC(=CC(=C1)Cl)NC2=NC3=C(C=CC(=C3)C(=O)O)C4=C2C=CN=C4.Cl |
| Reference | A Siddiqui-Jain et al. CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy. Cancer Res. 2010, 70, 10288-10298.
AD Ferguson et al. Structural basis of CX-4945 binding to human protein kinase CK2. FEBS Lett. 2011, 585(1), 104-110.
F Pierre et al. Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer. Mol. Cell Biochem. 2011, 356(1-2), 37-43. |
