CX-6258

• CAT Number: R061280
• CAS Number: 1353859-00-3
• Molecular Formula: C₂₆H₂₅Cl₂N₃O₃
• Molecular Weight: 498.4
• Purity: ≥95%
• Synonyms: (3E)-5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-Indol-2-one Hydrochloride
• Target: Pim
• Storage: RT
• IUPAC Name: (3E)-5-chloro-3-[[5-[3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl]furan-2-yl]methylidene]-1H-indol-2-one;hydrochloride
• InChI: InChI=1S/C26H24ClN3O3.ClH/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31;/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31);1H/b22-16+
• InChIKey: YYIMMVXTWBIEAG-YHLMHSEJSA-N
• SMILES: CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)C=C4C5=C(C=CC(=C5)Cl)NC4=O.Cl

CX-6258 HCl（Cat No.:R061280） is a highly potent and orally bioavailable pan-Pim kinase inhibitor with remarkable inhibitory activity against Pim1, Pim2, and Pim3 kinases. Its IC50 values are 5 nM, 25 nM, and 16 nM for Pim1, Pim2, and Pim3, respectively. As a pan-Pim kinase inhibitor, CX-6258 HCl exhibits great potential for therapeutic use in various diseases and conditions, particularly those associated with aberrant Pim kinase signaling, including certain types of cancer and other proliferative disorders.