CX717

• CAT Number: I025311
• CAS Number: 867276-98-0
• Molecular Formula: C11H11N3O3
• Molecular Weight: 233.23
• Purity: 98%
• Synonyms: Ampakine CX-717; Ampakine CX 717; Ampakine CX717; CX-717; CX 717; CX717
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2,1,3-Benzoxadiazol-5-yl(morpholin-4-yl)methanone
• InChI: InChI=1S/C11H11N3O3/c15-11(14-3-5-16-6-4-14)8-1-2-9-10(7-8)13-17-12-9/h1-2,7H,3-6H2
• InChIKey: KFRQROSRKSVROW-UHFFFAOYSA-N
• SMILES: O=C(C1=CC2=NON=C2C=C1)N3CCOCC3

CX717 (Cat No.: I025311) is an ampakine compound that enhances AMPA receptor activity, promoting synaptic plasticity and cognitive function. It has been studied for its potential to improve memory, learning, and attention in conditions such as Alzheimer’s disease, ADHD, and cognitive decline. CX717 also exhibits neuroprotective effects and has been explored for its ability to counteract sedation and respiratory depression. As a positive allosteric modulator of AMPA receptors, CX717 holds promise in neuroscience research and cognitive enhancement therapies, though further clinical validation is needed.

Reference

1: Purcell R, Lynch G, Gall C, Johnson S, Sheng Z, Stephen MR, Cook J, Garman RH, Jortner B, Bolon B, Radin D, Lippa A. Brain Vacuolation Resulting From Administration of the Type II Ampakine CX717 Is An Artifact Related to Molecular Structure and Chemical Reaction With Tissue Fixative Agents. Toxicol Sci. 2018 Apr 1;162(2):383-395. doi: 10.1093/toxsci/kfx277. PubMed PMID: 29253237.
2: Turner SM, ElMallah MK, Hoyt AK, Greer JJ, Fuller DD. Ampakine CX717 potentiates intermittent hypoxia-induced hypoglossal long-term facilitation. J Neurophysiol. 2016 Sep 1;116(3):1232-8. doi: 10.1152/jn.00210.2016. Epub 2016 Jun 15. PubMed PMID: 27306673; PubMed Central PMCID: PMC5018053.
3: Kara NZ, Flaisher-Grinberg S, Einat H. Partial effects of the AMPAkine CX717 in a strain specific battery of tests for manic-like behavior in black Swiss mice. Pharmacol Rep. 2015 Oct;67(5):928-33. doi: 10.1016/j.pharep.2015.02.008. Epub 2015 Mar 4. PubMed PMID: 26398387.
4: Ren J, Lenal F, Yang M, Ding X, Greer JJ. Coadministration of the AMPAKINE CX717 with propofol reduces respiratory depression and fatal apneas. Anesthesiology. 2013 Jun;118(6):1437-45. doi: 10.1097/ALN.0b013e318291079c. PubMed PMID: 23542802.
5: Ren J, Ding X, Greer JJ. Respiratory depression in rats induced by alcohol and barbiturate and rescue by ampakine CX717. J Appl Physiol (1985). 2012 Oct;113(7):1004-11. doi: 10.1152/japplphysiol.00752.2012. Epub 2012 Jul 26. PubMed PMID: 22837171; PubMed Central PMCID: PMC3487499.
6: Zheng Y, Balabhadrapatruni S, Masumura C, Darlington CL, Smith PF. Effects of the putative cognitive-enhancing ampakine, CX717, on attention and object recognition memory. Curr Alzheimer Res. 2011 Dec;8(8):876-82. PubMed PMID: 22171951.
7: Boyle J, Stanley N, James LM, Wright N, Johnsen S, Arbon EL, Dijk DJ. Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep. J Psychopharmacol. 2012 Aug;26(8):1047-57. doi: 10.1177/0269881111405353. Epub 2011 Sep 22. PubMed PMID: 21940760.
8: Ren J, Ding X, Funk GD, Greer JJ. Ampakine CX717 protects against fentanyl-induced respiratory depression and lethal apnea in rats. Anesthesiology. 2009 Jun;110(6):1364-70. doi: 10.1097/ALN.0b013e31819faa2a. PubMed PMID: 19461299.
9: Hampson RE, España RA, Rogers GA, Porrino LJ, Deadwyler SA. Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717. Psychopharmacology (Berl). 2009 Jan;202(1-3):355-69. doi: 10.1007/s00213-008-1360-z. Epub 2008 Nov 5. PubMed PMID: 18985324; PubMed Central PMCID: PMC3107999.
10: Porrino LJ, Daunais JB, Rogers GA, Hampson RE, Deadwyler SA. Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates. PLoS Biol. 2005 Sep;3(9):e299. Epub 2005 Aug 23. PubMed PMID: 16104830; PubMed Central PMCID: PMC1188239.