CXN37378

• CAT Number: I025315
• CAS Number: 1236037-37-8
• Molecular Formula: C27H31N3O4
• Molecular Weight: 461.56
• Purity: 98%
• Synonyms: NAP, CXN37378; CXN-37378; CXN 37378
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-Isonicotinoyl-beta-naltrexamine; N-((4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl)-3-methylisonicotinamide
• InChI: InChI=1S/C27H31N3O4/c1-15-13-28-10-7-18(15)25(32)29-19-6-8-27(33)21-12-17-4-5-20(31)23-22(17)26(27,24(19)34-23)9-11-30(21)14-16-2-3-16/h4-5,7,10,13,16,19,21,24,31,33H,2-3,6,8-9,11-12,14H2,1H3,(H,29,32)/t19-,21-,24+,26+,27-/m1/s1
• InChIKey: COQZBDBMRLFDRK-XGTKUTNFSA-N
• SMILES: O[C@@]1([C@@]23CC4)[C@@H](CC5=CC=C(O)C(O[C@H]3[C@H](NC(C(C=CN=C6)=C6C)=O)CC1)=C52)N4CC7CC7

CXN37378. NAP(CAT: I025315) is a potent and selective antagonist of the mu-opioid receptor (MOR), widely used in neuropharmacology and addiction research. By blocking MOR activity, NAP inhibits the effects of endogenous and exogenous opioids, making it a valuable tool for studying opioid receptor signaling, pain modulation, and the mechanisms underlying opioid dependence and tolerance. Its high specificity and efficacy provide reliable results in preclinical studies, facilitating the exploration of therapeutic strategies for managing pain, opioid use disorders, and related conditions. NAP is an essential compound for advancing MOR-targeted research and drug discovery.