CY-09

• CAT Number: I013063
• CAS Number: 1073612-91-5
• Molecular Formula: C₁₉H₁₂F₃NO₃S₂
• Molecular Weight: 423.43
• Purity: ≥95%
• Target: NOD-like Receptor (NLR)
• Solubility: DMSO
• IUPAC Name: 4-[(Z)-[4-oxo-2-sulfanylidene-3-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid
• InChI: InChI=1S/C19H12F3NO3S2/c20-19(21,22)14-3-1-2-12(8-14)10-23-16(24)15(28-18(23)27)9-11-4-6-13(7-5-11)17(25)26/h1-9H,10H2,(H,25,26)/b15-9-
• InChIKey: DJTINRHPPGAPLD-DHDCSXOGSA-N
• SMILES: C1=CC(=CC(=C1)C(F)(F)F)CN2C(=O)C(=CC3=CC=C(C=C3)C(=O)O)SC2=S

CY-09 (Cat.No:I013063) is a potent and specific inhibitor of the NLRP3 inflammasome, a crucial component of the immune system. It effectively blocks the activation of NLRP3, suppressing the release of pro-inflammatory cytokines. CY-09 shows potential for the treatment of inflammatory diseases. 

Reference

[1]. Jiang H, et al. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med. 2017 Nov 6;214(11):3219-3238.