Cyanine 5.5 azide

• CAT Number: I043078
• CAS Number: 1557136-25-0
• Molecular Formula: C43H49ClN6O
• Molecular Weight: 701.34
• Purity: ≥95%
• Synonyms: N-(3-azidopropyl)-6-[(2E)-1,1-dimethyl-2-[(2E,4E)-5-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)penta-2,4-dienylidene]benzo[e]indol-3-yl]hexanamide;chloride
• InChI: InChI=1S/C43H48N6O.ClH/c1-42(2)37(48(5)35-26-24-31-17-11-13-19-33(31)40(35)42)21-8-6-9-22-38-43(3,4)41-34-20-14-12-18-32(34)25-27-36(41)49(38)30-15-7-10-23-39(50)45-28-16-29-46-47-44;/h6,8-9,11-14,17-22,24-27H,7,10,15-16,23,28-30H2,1-5H3;1H
• InChIKey: KOVQVUIEVDGEDR-UHFFFAOYSA-N
• SMILES: CC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)C)C=CC=CC=C4C(C5=C(N4CCCCCC(=O)NCCCN=[N+]=[N-])C=CC6=CC=CC=C65)(C)C)C.[Cl-]

Cyanine 5.5 azide (CY 5.5 azide) is a potent fluorescent dye. Cyanine 5.5 azide can label DNA. Cyanine 5.5 azide can be used for NIR live organism imaging. (λex=684 nm, λem=710 nm)[1][2]. Cyanine 5.5 azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Reference

[1]. Sun H, et, al. Zwitterionic Cross-Linked Biodegradable Nanocapsules for Cancer Imaging. Langmuir. 2019 Feb 5;35(5):1440-1449.
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[2]. Damaj MI, et, al. In vivo characterization of a novel inhibitor of CNS nicotinic receptors. Eur J Pharmacol. 2005 Oct 3;521(1-3):43-8.
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