For research use only. Not for therapeutic Use.
Cyclacillin (Wy-4508) is an orally active aminopenicillin antibiotic, shows antibacterial activity against a wide range of gram-positive and gram-negative pathogens[1].
Cyclacillin (0-125 μg/mL) inhibits varies pathogens except Klebsiella an Enterobacter organisms with MIC values range from 0.24 μg/mL to 7.8 μg/mL[1].
Cyclacillin (0-287 mg/kg; p.o.; single dose) shows oral activity in mice and rescues mice injected with gram-positive and gram-negative pathogens[1].
Cyclacillin (10 mg/kg; i.v.; single dose) is absorbed by the rat intestinal tissue at relatively low concentrations (less than 1 mg/mL) followed solely Michaelis-Menten kinetics[2].
| Catalog Number | I006332 |
| CAS Number | 3485-14-1 |
| Synonyms | (2S,5R,6R)-6-[(1-aminocyclohexanecarbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Molecular Formula | C15H23N3O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C15H23N3O4S/c1-14(2)9(12(20)21)18-10(19)8(11(18)23-14)17-13(22)15(16)6-4-3-5-7-15/h8-9,11H,3-7,16H2,1-2H3,(H,17,22)(H,20,21)/t8-,9+,11-/m1/s1 |
| InChIKey | HGBLNBBNRORJKI-WCABBAIRSA-N |
| SMILES | CC1(C(N2C(S1)C(C2=O)NC(=O)C3(CCCCC3)N)C(=O)O)C |
| Reference | [1]. Warren GH. Cyclacillin: microbiological and pharmacological properties and use in chemotherapy of infection – a critical appraisal. Chemotherapy. 1976;22(3-4):154-82. |
