Cyclic GMP

• CAT Number: I025374
• CAS Number: 7665-99-8
• Molecular Formula: C10H12N5O7P
• Molecular Weight: 345.2078
• Purity: 98%
• Synonyms: Cyclic GMP; Guanosine cyclic monophosphate; cGMP
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-amino-9-((4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-1,9-dihydro-6H-purin-6-one
• InChI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1
• InChIKey: ZOOGRGPOEVQQDX-UUOKFMHZSA-N
• SMILES: NC1=Nc2n([C@@H]3O[C@@H]4COP(O)(O[C@H]4[C@H]3O)=O)cnc2C(N1)=O

Cyclic guanosine monophosphate (Cyclic GMP)(CAT: I025374), also known as cyclic GMP or cGMP, is a cyclic nucleotide derived from guanosine triphosphate (GTP). It serves as a critical second messenger molecule in various cellular signaling pathways. Cyclic GMP plays a key role in mediating the effects of extracellular peptide hormones that bind to cell surface receptors, leading to the activation of intracellular protein kinases. Through its interaction with specific protein kinases, cyclic GMP modulates various cellular processes, including ion channel regulation, smooth muscle relaxation, and gene expression.

Reference

1: Matera MG, Ora J, Cavalli F, Rogliani P, Cazzola M. New Avenues for Phosphodiesterase Inhibitors in Asthma. J Exp Pharmacol. 2021 Mar 15;13:291-302. doi: 10.2147/JEP.S242961. PMID: 33758554; PMCID: PMC7979323.