For research use only. Not for therapeutic Use.
Cyclic GMP sodium (cGMP) is an important regulator of short-term changes in smooth muscle tone and longer-term responses to chronic drug research or proliferative signals, it is in response to atrial natriuretic peptide (ANP) or nitric oxide (NO). Cyclic GMP sodium interacts with cation channels to regulate ion transport or activate the cyclic GMP-dependent protein kinase to result in protein phosphorylation[1][2].
| Catalog Number | R056883 |
| CAS Number | 40732-48-7 |
| Synonyms | sodium;9-[(4aR,6R,7aR)-7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-1H-purin-6-one |
| Molecular Formula | C10H11N5NaO7P |
| Purity | ≥95% |
| InChI | InChI=1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5?,6+,9-;/m1./s1 |
| InChIKey | KMPIYXNEROUNOG-CODPYOKSSA-M |
| SMILES | C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(O1)[O-].[Na+] |
| Reference | [1]. Rybalkin SD, et al. Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circ Res. 2003 Aug 22;93(4):280-91. [2]. Murad F. Shattuck Lecture. Nitric oxide and cyclic GMP in cell signaling and drug development. N Engl J Med. 2006 Nov 9;355(19):2003-11. doi: 10.1056/NEJMsa063904. PMID: 17093251. |
