For research use only. Not for therapeutic Use.
Cyclo(His-Pro) (CHP) (Cat No.: I006336) is a naturally occurring cyclic dipeptide involved in metabolic regulation and neuroprotection. It is a metabolite of thyrotropin-releasing hormone (TRH) and has been studied for its potential roles in glucose homeostasis, oxidative stress reduction, and cognitive function. CHP exhibits antioxidant and anti-inflammatory properties, making it valuable in diabetes, neurodegenerative disease, and aging research. Its ability to modulate insulin sensitivity and neuroprotection makes it a promising candidate for studying metabolic disorders, Alzheimer’s disease, and other related conditions.
| CAS Number | 53109-32-3 |
| Synonyms | Cyclo(his-pro);(3S,8aS)-3-((1H-imidazol-4-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione |
| Molecular Formula | C11H14N4O2 |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| IUPAC Name | (3S,8aS)-3-(1H-imidazol-5-ylmethyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione |
| InChI | 1S/C11H14N4O2/c16-10-9-2-1-3-15(9)11(17)8(14-10)4-7-5-12-6-13-7/h5-6,8-9H,1-4H2,(H,12,13)(H,14,16)/t8-,9-/m0/s1 |
| InChIKey | NAKUGCPAQTUSBE-IUCAKERBSA-N |
| SMILES | O=C(N[C@H]1CC2=CNC=N2)[C@@](CCC3)([H])N3C1=O |
| Reference | </br> 1:Kastin AJ, Pan W. Involvement of the Blood-Brain Barrier in Metabolic Regulation. CNS Neurol Disord Drug Targets. 2016 Sep 20. [Epub ahead of print] PubMed PMID: 27658512.</br> 2:Grottelli S, Ferrari I, Pietrini G, Peirce MJ, Minelli A, Bellezza I. The Role of Cyclo(His-Pro) in Neurodegeneration. Int J Mol Sci. 2016 Aug 12;17(8). pii: E1332. doi: 10.3390/ijms17081332. Review. PubMed PMID: 27529240; PubMed Central PMCID: PMC5000729. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
