Cyclo(-RGDfK) TFA

• CAT Number: I014846
• CAS Number: 500577-51-5
• Molecular Formula: C₂₉H₄₂F₃N₉O₉
• Molecular Weight: 717.69
• Purity: ≥95%
• Target: Integrin
• IUPAC Name: 2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;2,2,2-trifluoroacetic acid
• InChI: 1S/C27H41N9O7.C2HF3O2/c28-11-5-4-9-18-24(41)34-17(10-6-12-31-27(29)30)23(40)32-15-21(37)33-20(14-22(38)39)26(43)36-19(25(42)35-18)13-16-7-2-1-3-8-16;3-2(4,5)1(6)7/h1-3,7-8,17-20H,4-6,9-15,28H2,(H,32,40)(H,33,37)(H,34,41)(H,35,42)(H,36,43)(H,38,39)(H4,29,30,31);(H,6,7)/t17-,18-,19+,20-;/m0./s1
• InChIKey: WHCQIPJAWCYHFT-HXSCNMCGSA-N
• SMILES: C1C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=CC=C2)CC(=O)O.C(=O)(C(F)(F)F)O

Cyclo(-RGDfK) TFA (Cat No.: I014846) is a cyclic pentapeptide containing the RGD (Arg-Gly-Asp) motif, known for its high affinity and selectivity toward integrin receptors, particularly αvβ3. The cyclic structure enhances stability and binding specificity, making it valuable in targeting tumor angiogenesis and metastasis. The TFA (trifluoroacetate) salt form improves peptide handling and solubility. Cyclo(-RGDfK) is widely used in cancer research, drug delivery, and imaging applications, serving as a targeting moiety in nanoparticle systems and radiolabeled probes for integrin-positive tumor detection.

Reference

[1]. Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95.[2]. Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14.