Cyclobarbital calcium

• CAT Number: I025382
• CAS Number: 143-76-0
• Molecular Formula: C24H30CaN4O6
• Molecular Weight: 510.61
• Purity: 98%
• Synonyms: Cyclobarbital calcium; Hexemal; Hypnoval; Kollerdormfix; Nourydorm; Phanodorm; Reladorm
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: calcium 5-(cyclohex-1-en-1-yl)-5-ethyl-2,4,6-trioxotetrahydro-2H-pyrimidin-1-ide
• InChI: InChI=1S/2C12H16N2O3.Ca/c2*1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16;/h2*6H,2-5,7H2,1H3,(H2,13,14,15,16,17);/q;;+2/p-2
• InChIKey: LQOCSNZFBLPUID-UHFFFAOYSA-L
• SMILES: CCC1(C2=CCCCC2)C(NC([N-]C1=O)=O)=O.CCC3(C4=CCCCC4)C(NC([N-]C3=O)=O)=O.[Ca+2]

Cyclobarbital calcium(CAT: I025382) is a barbiturate derivative that functions as a central nervous system (CNS) depressant. It exerts its effects by enhancing the activity of gamma-aminobutyric acid (GABA) at GABAA receptors, leading to increased neuronal inhibition. This mechanism produces sedative, hypnotic, and anticonvulsant effects. Historically, Cyclobarbital calcium has been used for the treatment of insomnia, anxiety, and seizure disorders. However, due to its potential for dependence, tolerance, and toxicity, its clinical use has declined in favor of safer alternatives. Cyclobarbital calcium remains relevant in neuropharmacology research for studying CNS depression and GABAergic modulation.