Cyclobarbital calcium

• CAT Number: I025382
• CAS Number: 143-76-0
• Molecular Formula: C24H30CaN4O6
• Molecular Weight: 510.6
• Purity: 98%
• Synonyms: Cyclobarbital calcium; Hexemal; Hypnoval; Kollerdormfix; Nourydorm; Phanodorm; Reladorm
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: calcium 5-(cyclohex-1-en-1-yl)-5-ethyl-2,4,6-trioxotetrahydro-2H-pyrimidin-1-ide
• InChI: InChI=1S/2C12H16N2O3.Ca/c2*1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16;/h2*6H,2-5,7H2,1H3,(H2,13,14,15,16,17);/q;;+2/p-2
• InChIKey: LQOCSNZFBLPUID-UHFFFAOYSA-L
• SMILES: CCC1(C2=CCCCC2)C(NC([N-]C1=O)=O)=O.CCC3(C4=CCCCC4)C(NC([N-]C3=O)=O)=O.[Ca+2]

Cyclobarbital calcium is discontinued (DEA controlled substance). It is a barbiturate derivative.

Reference

1: HORSCH W. [Determination of cyclobarbital and cyclobarbital calcium]. Pharmazie. 1956 Jul;11(7):458-60. German. PubMed PMID: 13370326.
2: Breimer DD, Winten MA. Pharmacokinetics and relative bioavailability of cyclobarbital calcium in man after oral administration. Eur J Clin Pharmacol. 1976 Mar 22;09(5-6):443-50. PubMed PMID: 989475.
3: Breimer DD. Relative bioavailability of cyclobarbital calcium from aqueous solution compared to tablets. J Pharm Sci. 1975 Sep;64(9):1576-7. PubMed PMID: 1102661.
4: Kołaciński Z. [Evaluation of the usefulness of forced diuresis in patients with calcium cyclobarbital or reladorm poisoning]. Pol Tyg Lek. 1989 Jan 2;44(1):11-4. Polish. PubMed PMID: 2571141.
5: Breyer-Pfaff U, Seyfert H, Weber M, Egberts EH. Assessment of drug metabolism in hepatic disease: comparison of plasma kinetics of oral cyclobarbital and the intravenous aminopyrine breath test. Eur J Clin Pharmacol. 1984;26(1):95-101. PubMed PMID: 6143671.
6: Steudel H, Steudel A, von Unruh GE. Assay for cyclo-, seco- and pentobarbital by multiple ion detection: kinetics after a single dose. J Clin Chem Clin Biochem. 1982 Apr;20(4):267-9. PubMed PMID: 6122710.