Cycloguanil Hydrochloride

• CAT Number: R008546
• CAS Number: 152-53-4
• Molecular Formula: C11H15Cl2N5
• Molecular Weight: 288.18
• Purity: ≥95%
• Synonyms: 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine Hydrochloride; BN 2410; Chloroguanide Triazine Hydrochloride; Cycloguanil Hydrochloride; NSC 3074
• Target: DHFR
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine;hydrochloride
• InChI: InChI=1S/C11H14ClN5.ClH/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8;/h3-6H,1-2H3,(H4,13,14,15,16);1H
• InChIKey: MOUAPRKJJUXEIE-UHFFFAOYSA-N
• SMILES: CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C.Cl

Cycloguanil Hydrochloride (Cat No.:R008546) is a pharmacologically significant compound primarily utilized in antimalarial research. It targets the enzyme dihydrofolate reductase (DHFR) in Plasmodium falciparum, disrupting the synthesis of essential tetrahydrofolate cofactors required for nucleotide production. This inhibition hinders the parasite’s DNA and RNA replication, leading to growth arrest. Cycloguanil Hydrochloride demonstrates potent antimalarial properties, especially against drug-resistant Plasmodium falciparum strains. It has been employed in combination therapies for treating malaria, contributing to multidrug regimens to enhance efficacy and counter resistance.