Cycloguanil pamoate

For research use only. Not for therapeutic Use.

  • CAT Number: I006335
  • CAS Number: 609-78-9
  • Molecular Formula: C45H44Cl2N10O6
  • Molecular Weight: 891.81
  • Purity: ≥95%
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Cycloguanil pamoate (Cat. No: I006335) is an antimalarial compound that acts as a prodrug of cycloguanil, a potent dihydrofolate reductase (DHFR) inhibitor. It disrupts the folate pathway in malaria parasites, inhibiting DNA synthesis and cell replication, ultimately leading to the parasite’s death. Cycloguanil Pamoate is studied for its long-acting properties and potential in the prevention and treatment of malaria, particularly in combination therapies. Its sustained-release formulation makes it valuable for prolonged therapeutic effects, and it plays an important role in research aimed at combating drug-resistant strains of Plasmodium species, offering insights into more effective malaria treatments.


Catalog Number I006335
CAS Number 609-78-9
Synonyms

Cycloguanil pamoate; Cycloguanil embonate; C11724; D02387.;2-Naphthalenecarboxylic acid, 4,4/’-methylenebis(3-hydroxy-, compd. with 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine (1:2)

Molecular Formula C45H44Cl2N10O6
Purity ≥95%
Solubility Soluble in DMSO, not in water
Storage 0 - 4°C for short term ,or -20 °C for long term
IUPAC Name 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
InChI InChI=1S/C23H16O6.2C11H14ClN5/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;2*1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2*3-6H,1-2H3,(H4,13,14,15,16)
InChIKey LUNRMKZYOGNOTR-UHFFFAOYSA-N
SMILES CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C.CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O

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