For research use only. Not for therapeutic Use.
Cyclohexane-PEG1-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I044729 |
| CAS Number | 131665-94-6 |
| Synonyms | 2-bromoethoxycyclohexane |
| Molecular Formula | C8H15BrO |
| Purity | ≥95% |
| InChI | InChI=1S/C8H15BrO/c9-6-7-10-8-4-2-1-3-5-8/h8H,1-7H2 |
| InChIKey | RIEJARKPVINFOD-UHFFFAOYSA-N |
| SMILES | C1CCC(CC1)OCCBr |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
