Cyclo(L-Phe-L-Val)

• CAT Number: R071864
• CAS Number: 35590-86-4
• Molecular Formula: C14H18N2O2
• Molecular Weight: 246.30
• Purity: ≥95%
• Synonyms: (3S,6S)-3-benzyl-6-propan-2-ylpiperazine-2,5-dione
• InChI: InChI=1S/C14H18N2O2/c1-9(2)12-14(18)15-11(13(17)16-12)8-10-6-4-3-5-7-10/h3-7,9,11-12H,8H2,1-2H3,(H,15,18)(H,16,17)/t11-,12-/m0/s1
• InChIKey: OQQPOHUVAQPSHJ-RYUDHWBXSA-N
• SMILES: CC(C)C1C(=O)NC(C(=O)N1)CC2=CC=CC=C2

Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL). cyclo(L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions[1].
Cyclo(L-Phe-L-Val) (32 μg/mL; 2 d) decreases icl product in C. albicans SC5314 (wild-type), MRC10 (Δicl), and MRC11 (Δicl + ICL), respectively[1].

Reference

[1]. Kim H, et al. Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans. Molecules. 2019 Jun 4;24(11):2111.
 [Content Brief]