Cyclo(L-Trp-L-Trp)

• CAT Number: I011886
• CAS Number: 20829-55-4
• Molecular Formula: C22H20N4O2
• Molecular Weight: 372.42
• Purity: ≥95%
• Synonyms: (3S,6S)-3,6-bis(1H-indol-3-ylmethyl)piperazine-2,5-dione
• InChI: InChI=1S/C22H20N4O2/c27-21-19(9-13-11-23-17-7-3-1-5-15(13)17)25-22(28)20(26-21)10-14-12-24-18-8-4-2-6-16(14)18/h1-8,11-12,19-20,23-24H,9-10H2,(H,25,28)(H,26,27)/t19-,20-/m0/s1
• InChIKey: DNHODRZUCGXYKU-PMACEKPBSA-N
• SMILES: C1=CC=C2C(=C1)C(=CN2)CC3C(=O)NC(C(=O)N3)CC4=CNC5=CC=CC=C54

Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research[1].
Cyclo(L-Trp-L-Trp) can inhibit A. baumannii (MICs=12.5-25 µg/mL), as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus (MICs=12.5-50 µg/mL)[1].

Reference

[1]. Keyong Ho Lee, et al. Identification of Streptomyces sp. KH29, which produces an antibiotic substance processing an inhibitory activity against multidrug-resistant Acinetobacter baumannii. J Microbiol Biotechnol. 2010 Dec;20(12):1672-6.
 [Content Brief]