Cyclooctyne-O-NHS ester

• CAT Number: I017850
• CAS Number: 1425803-45-7
• Molecular Formula: C₁₄H₁₇NO₅
• Molecular Weight: 279.29
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 2-cyclooct-2-yn-1-yloxyacetate
• InChI: InChI=1S/C14H17NO5/c16-12-8-9-13(17)15(12)20-14(18)10-19-11-6-4-2-1-3-5-7-11/h11H,1-4,6,8-10H2
• InChIKey: KSXCIPWSNSHGIM-UHFFFAOYSA-N
• SMILES: C1CCC#CC(CC1)OCC(=O)ON2C(=O)CCC2=O

Cyclooctyne-O-NHS ester (Cat No.: I017850) is an ADC linker that can be cleaved for the synthesis of antibody-drug conjugates. It is used to link a drug molecule to an antibody through a cleavable linker, allowing the drug to be released in the targeted area. This linker provides a stable and efficient platform for the development of ADCs. It is a valuable tool in cancer research and drug development.

Reference

[1]. Tao Wang, et al. Design and synthesis of tumor-targeting theranostic drug conjugates for SPECT and PET imaging studies. Bioorg Chem. 2018 Feb;76:458-467.