Cyclooctyne-O-NHS ester

For research use only. Not for therapeutic Use.

  • CAT Number: I017850
  • CAS Number: 1425803-45-7
  • Molecular Formula: C₁₄H₁₇NO₅
  • Molecular Weight: 279.29
  • Purity: ≥95%
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Cyclooctyne-O-NHS ester (Cat No.: I017850) is an ADC linker that can be cleaved for the synthesis of antibody-drug conjugates. It is used to link a drug molecule to an antibody through a cleavable linker, allowing the drug to be released in the targeted area. This linker provides a stable and efficient platform for the development of ADCs. It is a valuable tool in cancer research and drug development.


Catalog Number I017850
CAS Number 1425803-45-7
Molecular Formula C₁₄H₁₇NO₅
Purity ≥95%
Target ADC Linker
IUPAC Name (2,5-dioxopyrrolidin-1-yl) 2-cyclooct-2-yn-1-yloxyacetate
InChI InChI=1S/C14H17NO5/c16-12-8-9-13(17)15(12)20-14(18)10-19-11-6-4-2-1-3-5-7-11/h11H,1-4,6,8-10H2
InChIKey KSXCIPWSNSHGIM-UHFFFAOYSA-N
SMILES C1CCC#CC(CC1)OCC(=O)ON2C(=O)CCC2=O
Reference

[1]. Tao Wang, et al. Design and synthesis of tumor-targeting theranostic drug conjugates for SPECT and PET imaging studies. Bioorg Chem. 2018 Feb;76:458-467.

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