For research use only. Not for therapeutic Use.
Cyclopropaneacetamide-Exatecan(CAT: I040872) is a conjugate of a cyclopropaneacetamide moiety and Exatecan, a potent DNA topoisomerase I inhibitor. Exatecan interferes with DNA replication by stabilizing the DNA-topoisomerase I cleavage complex, leading to DNA breaks and subsequent cancer cell death. The cyclopropaneacetamide group enhances the drug’s stability and pharmacokinetics, improving its therapeutic potential. Cyclopropaneacetamide-Exatecan is primarily being investigated in Cancer Disease Research for its ability to selectively target and kill tumor cells by inducing DNA damage, offering a potential treatment for cancers that are resistant to conventional chemotherapy agents, particularly those involving topoisomerase I-mediated DNA repair pathways.
| CAS Number | 2414254-36-5 |
| Synonyms | (2S)-2-cyclopropyl-N-[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]-2-hydroxyacetamide |
| Molecular Formula | C29H28FN3O6 |
| Purity | ≥95% |
| IUPAC Name | (2S)-2-cyclopropyl-N-[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]-2-hydroxyacetamide |
| InChI | InChI=1S/C29H28FN3O6/c1-3-29(38)17-8-21-24-15(10-33(21)27(36)16(17)11-39-28(29)37)23-19(32-26(35)25(34)13-4-5-13)7-6-14-12(2)18(30)9-20(31-24)22(14)23/h8-9,13,19,25,34,38H,3-7,10-11H2,1-2H3,(H,32,35)/t19-,25-,29-/m0/s1 |
| InChIKey | ODYAHADGPIHDQN-AHGJQYSPSA-N |
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C5C(CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)NC(=O)C(C7CC7)O)O |
