For research use only. Not for therapeutic Use.
Cyclopyrimorate, a highly effective bleaching herbicide for weed control in rice fields, targets homogentisate solanesyltransferase (HST). HST is a downstream enzyme of 4-hydroxyphenylpyruvate dioxygenase in the plastoquinone (PQ) biosynthesis pathway[1][2].
Cyclopyrimorate-dependent bleaching effect on Arabidopsis thaliana is reversed by decyl PQ, suggesting that this symptom is attributable to the inhibition of PQ biosynthesis[1].
| Catalog Number | I006339 |
| CAS Number | 499231-24-2 |
| Synonyms | [6-chloro-3-(2-cyclopropyl-6-methylphenoxy)pyridazin-4-yl] morpholine-4-carboxylate |
| Molecular Formula | C19H20ClN3O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H20ClN3O4/c1-12-3-2-4-14(13-5-6-13)17(12)27-18-15(11-16(20)21-22-18)26-19(24)23-7-9-25-10-8-23/h2-4,11,13H,5-10H2,1H3 |
| InChIKey | BXIGJZDQFDFASM-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=CC=C1)C2CC2)OC3=NN=C(C=C3OC(=O)N4CCOCC4)Cl |
| Reference | [1]. Shino M, et al. In vivo and in vitro evidence for the inhibition of homogentisate solanesyltransferase by cyclopyrimorate. Pest Manag Sci. 2019 Nov 27. [2]. Shino M, et al. Action mechanism of bleaching herbicide cyclopyrimorate, a novel homogentisate solanesyltransferase inhibitor. J Pestic Sci. 2018 Nov 20;43(4):233-239. |
