Cyclosporin A acetate-d4

• CAT Number: S000501
• Molecular Formula: C64H109D4N11O13
• Molecular Weight: 1248.67
• Purity: ≥95%
• IUPAC Name: [(E,1R,2R)-5,6,6,6-tetradeuterio-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacont-2-yl]-2-methylhex-4-enyl] acetate
• InChI: InChI=1S/C64H113N11O13/c1-26-28-29-41(15)54(88-44(18)76)53-58(81)67-45(27-2)60(83)69(19)34-50(77)70(20)46(30-35(3)4)57(80)68-51(39(11)12)63(86)71(21)47(31-36(5)6)56(79)65-42(16)55(78)66-43(17)59(82)72(22)48(32-37(7)8)61(84)73(23)49(33-38(9)10)62(85)74(24)52(40(13)14)64(87)75(53)25/h26,28,35-43,45-49,51-54H,27,29-34H2,1-25H3,(H,65,79)(H,66,78)(H,67,81)(H,68,80)/b28-26+/t41-,42+,43-,45+,46+,47+,48+,49+,51+,52+,53+,54-/m1/s1/i1D3,26D
• InChIKey: KUSICUWKCBCAHV-UWDCJETPSA-N
• SMILES: CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)OC(=O)C)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

Cyclosporin A acetate-d4（Cat No.:S000501） is a deuterated version of cyclosporin A acetate, where four hydrogen atoms are replaced with deuterium. Cyclosporin A is a potent immunosuppressive compound widely used to prevent organ transplant rejection and to treat autoimmune diseases. It functions by inhibiting the activity of T-cells. The acetate form is a derivative with potentially enhanced solubility. Introducing deuterium into cyclosporin A acetate enhances its metabolic stability, allowing for more precise pharmacokinetic studies.